2026-10-15 分子科学研究所
＜関連情報＞
- https://www.ims.ac.jp/news/2026/10/1015.html
- https://pubs.acs.org/jacsat/article-abstract/doi/10.1021/jacs.6c17351/5449468/Armor-Shape-Complementary-Encapsulation-of
π-アーマー：芳香族化合物の形状相補的カプセル化 π-Armor: Shape-Complementary Encapsulation of Aromatics
Haruka Kano;Takashi Harimoto;Yasutomo Segawa
Journal of the American Chemical Society Published:October 13, 2026
DOI:https://doi.org/10.1021/jacs.6c17351
Abstract
Host–guest binding can be classified into two well-separated modes, i.e., reversible binding under thermodynamic control and permanent encapsulation via kinetic trapping during host formation. However, combining both modes within a single π-conjugated host on the basis of host–guest shape complementarity has remained challenging. Here, we present the design and synthesis of a neutral D3-symmetric π-conjugated cage (1), wherein two curved hexa-cata-hexabenzocoronene (c-HBC) panels are bridged by dibenzodiazocine (DBDA) units to form three orifices and a biconvex nanocavity. Cage 1 reversibly encapsulates aromatic guests, whereby binding affinities are governed by dispersion arising from shape complementarity. In contrast, bulky guests that are too large to pass through the orifices are incorporated during cage formation and permanently entrapped, affording thermally robust carceplexes. Even a π-extended guest exceeding the cavity size was entrapped, with its aryl groups protruding through the three orifices to form a mechanically interlocked molecule. Thus, cage 1 behaves as a dual-mode host controlled by shape complementarity, representing a “π-armor” that sandwiches aromatic guests between its π-surfaces.
