水素で「止めたいところに止める」有機合成を実現 ー単原子白金触媒により、医薬品関連分子の合成に有用なニトロンを高選択的・連続的に合成ー

2026-06-30 東京大学

単原子白金触媒による選択的水素化反応

＜関連情報＞

• https://www.s.u-tokyo.ac.jp/ja/press/11173/
• https://pubs.acs.org/doi/10.1021/jacs.6c08609

N,Pドープ炭素上の単原子白金触媒によるニトロ化合物とアルデヒドのカスケード水素化カップリングを介した選択的ニトロン合成 Selective Nitrone Synthesis via Cascade Hydrogenative Coupling of Nitro Compounds and Aldehydes Catalyzed by Single-Atom Platinum on N,P-Doped Carbon

Taisei Senzaki,Tomohiro Yasukawa,Yasuhiro Yamashita,Tei Maki,Muneaki Yamamoto,Tomoko Yoshida,Kai Oshiro,Min Gao,and Shu̅ Kobayashi
Journal of the American Chemical Society  Published: June 26, 2026
DOI:https://doi.org/10.1021/jacs.6c08609

Abstract

Single-atom catalysts have emerged as powerful platforms for selective hydrogenation reactions owing to their well-regulated active sites; however, their unique reactivity in cascade hydrogenation processes remains relatively unexplored. Herein, we report that a single-atom platinum catalyst supported on N,P-doped carbon efficiently catalyzes the cascade hydrogenative coupling of nitro compounds and aldehydes, leading to the highly selective synthesis of nitrones. This catalytic system enables the facile production of 40 diverse nitrones, including those derived from aromatic and aliphatic substrates, as well as important intermediates of bioactive compounds. In sharp contrast to nanoparticle catalysts that promote over-reduction, this Pt single-atom platform exhibits broad functional-group tolerance, accommodating reducible C═C and C═O bonds and aryl halides. Furthermore, the catalyst demonstrates robust durability in a continuous-flow system, providing an atom-economical and sustainable methodology for nitrone synthesis.