2026-09-21 中国科学院（CAS）
Electrocatalytic coupling of CO2 and HPO32− (Image by WANG Hengan)
＜関連情報＞
- https://english.cas.cn/newsroom/research-news/202609/t20260922_1201105.shtml
- https://www.nature.com/articles/s41929-026-01608-6
ホスカルネット合成のためのCO₂と亜リン酸エステルの電気化学的カップリング Electrochemical coupling of CO2 and phosphite for foscarnet synthesis
Hengan Wang, Ran Duan, Yiyong Wang, Meng Zhou, Wenling Zhao, Jiahao Yang, Yaoyu Yin, Shipeng Zhang, Shiqiang Liu, Zhongnan Ling, Huisheng Qin, Ke Li, Xing Tong, Pei Zhang, Qinggong Zhu, Yi Xu, Xinchen Kang & Buxing Han
Nature Catalysis Published:25 August 2026
DOI:https://doi.org/10.1038/s41929-026-01608-6
Abstract
Foscarnet is a clinically vital antiviral drug with substantial market value, yet its conventional synthesis remains challenging. The coupling of CO2 with phosphite represents an attractive and sustainable alternative route for foscarnet production, although this approach has not been successfully demonstrated so far. Here we show the electrosynthesis of foscarnet via the coupling of CO2 and phosphite, enabled by an ionic liquid-modified bismuth (IL@Bi) catalyst. The IL@Bi catalyst achieves a Faradaic efficiency of 37.5% towards foscarnet with a current density of 224.2 mA cm−2. The production rate over IL@Bi is 1,555.6 μmol cm−2 h−1, which is ten times higher than that over unmodified Bi. Mechanistic studies reveal that the IL in IL@Bi enhances the generation of CO2·− radicals in the electrolyte through IL radical-mediated electron transfer. It also facilitates the encounter between CO2·− and PO3·2−, enabling efficient foscarnet synthesis.
