2025-10-08 京都大学
世界のコムギ9品種から遺伝子発現マップを作成
＜関連情報＞
- https://www.kyoto-u.ac.jp/ja/research-news/2025-10-08
- https://www.kyoto-u.ac.jp/sites/default/files/2025-10/web_2510_Nasuda-0f91498f522ce43d3de8e9f29ce4065e.pdf
- https://www.nature.com/articles/s41467-025-64046-1
de novoアノテーションにより、六倍体小麦全ゲノムのトランスクリプトームの複雑さが明らかになった De novo annotation reveals transcriptomic complexity across the hexaploid wheat pan-genome
Benjamen White,Thomas Lux,Rachel Rusholme-Pilcher,Angéla Juhász,Gemy Kaithakottil,Susan Duncan,James Simmonds,Hannah Rees,Jonathan Wright,Joshua Colmer,Sabrina Ward,Ryan Joynson,Benedict Coombes,Naomi Irish,Suzanne Henderson,Tom Barker,Helen Chapman,Leah Catchpole,Karim Gharbi,Utpal Bose,Moeko Okada,Hirokazu Handa,Shuhei Nasuda,Kentaro K. Shimizu,10+ Wheat Genome Project,… Anthony Hal
Nature Communications Published:06 October 2025
DOI:https://doi.org/10.1038/s41467-025-64046-1
Abstract
Wheat is the most widely cultivated crop in the world, with over 215 million hectares grown annually. The 10+ Wheat Genomes Project recently sequenced and assembled to chromosome-level the genomes of nine wheat cultivars, uncovering genetic diversity and selection within the pan-genome of wheat. Here, we provide a wheat pan-transcriptome with de novo annotation and differential expression analysis for these wheat cultivars across multiple tissues. Using the de novo annotations we identify cultivar-specific genes and define the core and dispensable genomes. Expression analysis across cultivars and tissues reveals conservation in expression between a large core set of homeologous genes, in addition to widespread changes in subgenome homeolog expression bias between cultivars and cultivar-specific expression profiles. We utilise both the newly constructed gene-based wheat pan-genome and pan-transcriptome, demonstrating variation in the prolamin superfamily and immune-reactive proteins across cultivars.
