研究者らがポイントオブケア質量分析計の主要部品を3Dプリント(Researchers 3D print key components for a point-of-care mass spectrometer)

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2024-04-04 マサチューセッツ工科大学(MIT)

質量分析法は、サンプルの化学成分を識別するための有力な技術ですが、高価な質量分析装置は一般的には研究室でのみ使用されます。MITの研究者らは、低コストの3Dプリントイオナイザーを開発し、これを質量分析装置に組み込むことで、慢性疾患の患者が自宅で健康を管理できるようになる可能性があります。この技術は、将来的に臨床診断で広く利用される可能性があります。

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高性能、低コスト、積層造形による質量分析用エレクトロスプレーイオン源 High-Performance, Low-Cost, Additively Manufactured Electrospray Ion Sources for Mass Spectrometry

Alex Kachkine and Luis Fernando Velásquez-García
Journal of the American Association for Mass Spectrometry  Published:March 22, 2024
DOI:https://doi.org/10.1021/jasms.3c00409

Abstract

研究者らがポイントオブケア質量分析計の主要部品を3Dプリント(Researchers 3D print key components for a point-of-care mass spectrometer)

We report novel 3D-printed electrospray sources for mass spectrometry (MS) that produce twice the signal strength of their mainstream counterparts. Leveraging 3D printing to fabricate in bulk nano- and microscale-featured electrospray emitters, this work shows a path for scalable integration in clinically relevant diagnostics. This solution improves the device performance by simultaneously tuning the surface hydrophilicity, solvent evaporation, and geometry. The emitters are made of stainless-steel (SS) 316L via binder jetting and coated in a conformal, hydrothermally grown zinc oxide nanowire (ZnONW) forest. The printed emitters are designed as surface mount devices that can be directly soldered to printed circuit boards with built-in digital microfluidics as part of an automated device assembly. The electrospray sources use a novel extractor electrode design that enables operation at ∼24% larger bias voltages compared with conventional MS cylindrical inlets. The 3D-printed electrospray emitters were characterized against their state-of-the-art counterparts (coated blades and paper spray). MS data from the 3D-printed electrospray emitters show detection of therapeutically relevant targets at 1 μg/ml concentrations with a variety of solvents; for nicardipine, such emitters attain 116% higher signal-to-noise ratios and far greater stability than their counterparts.

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