2026-09-16 韓国基礎科学研究院（IBS）
Figure 1. Idea behind the project in a snapshot
A systematic scan across reaction hyperspace using a robotic platform leds to the discovery of unexpected reactivity and complex bicyclic product from simple substrates. The result from the robotic campaign inspires the synthesis of a new scaffold.
＜関連情報＞
- https://www.ibs.re.kr/cop/bbs/BBSMSTR_000000000738/selectBoardArticle.do?nttId=27022&pageIndex=1&searchCnd=&searchWrd=#
- https://www.nature.com/articles/s44160-026-01096-3
- https://tiisys.com/blog/2025/09/25/post-176161/
ロボット工学を用いたハイパースペース探査による、機構的に異なる変換と複雑な機能性生成物の発見 Hyperspace exploration using robotics for the discovery of mechanistically distinct transformations and complex functional products
Daniel Matuszczyk,Rafał Frydrych,Wai-Shing Wong,Yankai Jia,Yaroslav I. Sobolev,Jan Hanus,Juhyeong Lee & Bartosz A. Grzybowski
Nature Synthesis Published:02 July 2026
DOI:https://doi.org/10.1038/s44160-026-01096-3
Abstract
Chemical reactions are traditionally viewed as linear transformations, yet in reality they unfold as mechanistic networks embedded within multidimensional ‘hyperspaces’ of conditions. Systematic exploration of these spaces can redirect classical reactions into unexpected branches representing new reactivity patterns. Here we report the discovery of a pseudo-seven-component transformation within the hyperspace of the century-old Biginelli reaction, yielding polycyclic products with substantial structural and stereochemical complexity. These products also exhibit rare supramolecular behaviours, from hierarchical assembly to metal-programmed chiral sorting. Together, these findings demonstrate that hyperspace exploration can uncover mechanistically distinct and functionally useful reactions, expanding the boundaries of chemical reactivity.
