2026-09-15 京都大学
分子量の小さな低分子化合物のみから構成される、結晶性の「超分子材料」 （杉安研究室 Cheng Chia-Hsin作成）
＜関連情報＞
- https://www.t.kyoto-u.ac.jp/ja/research/topics/20260915
- https://www.nature.com/articles/s41467-026-77392-5
コレステロールをベースとした低分子量化合物の過冷却液晶相から調製された巨視的に異方性のある超分子材料 Macroscopically anisotropic supramolecular materials prepared from an undercooled liquid-crystalline phase of a cholesterol-based low-molecular-weight compound
Chia-Hsin Cheng,Yuichiro Watanabe,Takashi Kajitani,Sadaki Samitsu & Kazunori Sugiyasu
Nature Communications Published:11 September 2026
DOI:https://doi.org/10.1038/s41467-026-77392-5
Abstract
Supramolecular bulk materials composed of low-molecular-weight compounds offer a promising pathway toward sustainable materials. However, achieving a macroscopic structural order and tuneable mechanical properties without relying on covalently bonded macromolecular components remains a significant challenge. We develop a supramolecular material derived from a cholesterol-based low-molecular-weight compound, (3β)-cholest-5-en-3-yl dodecylcarbamate, that forms a metastable liquid-crystalline (LC) phase upon quenching from its isotropic melt. The LC phase displays sufficient fluidity at room temperature to permit bulk processing, for example, by compression; the material subsequently undergoes spontaneous crystallization to form a self-standing sheet. By controlling the quenching temperature and the incubation time prior to processing, we succeed in endowing the sheet with molecular ordering that extends beyond the centimetre scale and, as a result, the sheet exhibits anisotropic mechanical properties. These findings establish a design strategy for creating processable, structurally tuneable, bulk materials exclusively from small molecules.
