2026-02-23 エディンバラ大学
＜関連情報＞
- https://www.ed.ac.uk/news/breadcrumbs-lead-to-fossil-free-production-of-everyday-goods
- https://www.nature.com/articles/s41557-025-02052-y
天然のH 2経路は細菌における代謝アルケンの生体適合性水素化を可能にする Native H2 pathways enable biocompatible hydrogenation of metabolic alkenes in bacteria
Mirren F. M. White,Connor L. Trotter,John F. C. Steele,Elizabeth C. H. T. Lau,Jhuma Sadhukhan,Yuta Era,Samantha Law,James Gilman,Jonathan A. Dennis,Nick W. Johnson,Rory Gordon & Stephen Wallace
Nature Chemistry Published:23 February 2026
DOI:https://doi.org/10.1038/s41557-025-02052-y
Abstract
Hydrogen gas is naturally produced by microorganisms from renewable feedstocks, yet industrial hydrogenation relies almost entirely on fossil fuel-derived H2. Despite advances in engineering biology and increasing demand for greener manufacturing, microbial H2 has seen limited application in chemical synthesis. Here we demonstrate that genetically unmodified microorganisms can generate H2 in situ to drive biocompatible alkene hydrogenation at the cell membrane using membrane-bound Pd catalysts. When combined with de novo alkene biosynthesis in engineered Escherichia coli, this system enables the simultaneous in vivo production of both substrate (alkene) and reagent (H2), followed by membrane-associated biohydrogenation to yield new metabolic end products. Quantitative life cycle assessment reveals that hybrid chemo-microbial systems utilizing waste feedstocks can outperform electrolytic hydrogenation and achieve carbon-negative outcomes. Together, this work demonstrates how microbial metabolites can be generated, intercepted and metabolically multiplexed to support biocompatible transition metal catalysis and sustainable chemical synthesis in living cells.
