2023-12-08 デンマーク工科大学(DTU)
◆NVセンターと呼ばれる色の中心を使用し、これにより組織への侵入が不要であり、非侵襲的な方法で脳組織からの信号を検出できます。この手法はまだ初期段階ですが、磁場変化を測定するために特殊な機器が不要で、生きた組織からの測定に適しています。
＜関連情報＞
- https://www.dtu.dk/english/news/all-news/diamond-quantum-sensors-can-measure-neuron-activity-in-the-brain
- https://www.nature.com/articles/s41598-023-39539-y
ダイヤモンド量子センサーを用いた脳神経細胞の電気活動の微視的磁気記録Microscopic-scale magnetic recording of brain neuronal electrical activity using a diamond quantum sensor
Nikolaj Winther Hansen,James Luke Webb,Luca Troise,Christoffer Olsson,Leo Tomasevic,Ovidiu Brinza,Jocelyn Achard,Robert Staacke,Michael Kieschnick,Jan Meijer,Axel Thielscher,Hartwig Roman Siebner,Kirstine Berg-Sørensen,Jean-François Perrier,Alexander Huck & Ulrik Lund Andersen
Scientific Reports Published:31 July 2023
DOI:https://doi.org/10.1038/s41598-023-39539-y
Abstract
Quantum sensors using solid state qubits have demonstrated outstanding sensitivity, beyond that possible using classical devices. In particular, those based on colour centres in diamond have demonstrated high sensitivity to magnetic field through exploiting the field-dependent emission of fluorescence under coherent control using microwaves. Given the highly biocompatible nature of diamond, sensing from biological samples is a key interdisciplinary application. In particular, the microscopic-scale study of living systems can be possible through recording of temperature and biomagnetic field. In this work, we use such a quantum sensor to demonstrate such microscopic-scale recording of electrical activity from neurons in fragile living brain tissue. By recording weak magnetic field induced by ionic currents in mouse corpus callosum axons, we accurately recover signals from neuronal action potential propagation while demonstrating in situ pharmacology. Our sensor allows recording of the electrical activity in neural circuits, disruption of which can shed light on the mechanisms of disease emergence. Unlike existing techniques for recording activity, which can require potentially damaging direct interaction, our sensing is entirely passive and remote from the sample. Our results open a promising new avenue for the microscopic recording of neuronal signals, offering the eventual prospect of microscopic imaging of electrical activity in the living mammalian brain.
