2025-09-30 東京大学
Web要約 の発言:
分子や動物・人間社会など、確率的に振る舞う生物集団の制御の概念図
<関連情報>
- https://www.iis.u-tokyo.ac.jp/ja/news/4874/
- https://journals.aps.org/prxlife/abstract/10.1103/zttn-tpzq
エントロピー制御コストとモードスイッチング戦略の出現を伴う確率的反応ネットワークの最適制御 Optimal Control of Stochastic Reaction Networks with Entropic Control Cost and Emergence of Mode-Switching Strategies
Shuhei A. Horiguchi and Tetsuya J. Kobayashi
PRX Life Published: 26 September, 2025
DOI: https://doi.org/10.1103/zttn-tpzq
Abstract
Controlling the stochastic dynamics of biological populations is a challenge that arises across various biological contexts. However, these dynamics are inherently nonlinear and involve a discrete state space, i.e., the number of molecules, cells, or organisms. Additionally, the possibility of extinction has a significant impact on both dynamics and control strategies, particularly when the population size is small. These factors hamper the direct application of conventional control theories to biological systems. To address these challenges, we formulate the optimal control problem for stochastic population dynamics by utilizing control cost functions based on the -divergence, which naturally accounts for population-specific factors. If Kullback-Leibler divergence is adopted for the cost function, the complex nonlinear Hamilton-Jacobi-Bellman equation is simplified into a linear form, facilitating efficient computation of optimal solutions. We demonstrate the effectiveness of our approach by applying it to the control of interacting random walkers, Moran processes, and SIR models, and observe the mode-switching phenomena in the control strategies. Our approach provides new opportunities for applying control theory to a wide range of biological problems.
