自己発光型バイオセンサーの初実装に成功(EPFL scientists build first self-illuminating biosensor)

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2025-06-26 スイス連邦工科大学ローザンヌ校(EPFL)

自己発光型バイオセンサーの初実装に成功(EPFL scientists build first self-illuminating biosensor)A metasurface of gold nanowires drives quantum light emission and concentrates the resulting light waves to detect biomolecules. 2025 Ella Maru Studio/BIOS EPFL CC BY SA 4.0

スイス・ローザンヌ工科大学(EPFL)の研究チームは、外部光源を必要とせず自己発光するバイオセンサーを世界で初めて開発しました。これは、金ナノワイヤーのメタサーフェスを利用し、量子光学的に生体分子の存在を検出する技術で、光ファイバを介した生体信号の読み取りを可能とします。光源不要で、医療・環境モニタリング向けに小型・低コストかつ高度な検出精度を実現する点が特長です。詳細はEPFLのTech Transfer部門で公開されました

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共鳴量子トンネリングが可能にするプラズモニック・バイオセンサー Plasmonic biosensor enabled by resonant quantum tunnelling

Jihye Lee,Yina Wu,Ivan Sinev,Mikhail Masharin,Sotirios Papadopoulos,Eduardo J. C. Dias,Lujun Wang,Ming Lun Tseng,Seunghwan Moon,Jong-Souk Yeo,Lukas Novotny,F. Javier García de Abajo & Hatice Altug
Nature Photonics  Published:26 June 2025
DOI:https://doi.org/10.1038/s41566-025-01708-y

Abstract

Metasurfaces provide an ideal platform for optical sensing because they produce strong light-field confinement and enhancement over extended regions that allow us to identify deep-subwavelength layers of organic and inorganic molecules. However, the requirement of using external light sources involves bulky equipment that hinders point-of-care applications. Here we introduce a plasmonic sensor with an embedded source of light provided by quantum tunnel junctions. An optically resonant, doubly periodic nanowire metasurface serves as a top contact for the junction and provides extremely uniform emission over large areas, amplified by plasmonic nanoantenna modes that simultaneously enhance the spectral and refractive index sensitivity. As a proof of concept, we demonstrate spatially resolved refractometric sensing of nanometre-thick polymer and biomolecule coatings. Our results open exciting prospects based on a disruptive platform for integrated electro-optical biosensors.

0505化学装置及び設備
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