動物を生検する手間が省け、培養肉の無限の可能性を秘めた幹細胞 Reducing the need to biopsy animals, the stem cells provide a potentially endless source for cultured meat
2023-05-11 タフツ大学
◆この進歩により、世界中の研究者や企業が、農場動物の生検から細胞を繰り返し調達する必要がなく、新しい製品を開発できるようになりました。不死化細胞を広く提供することで、セルラー農業を探索する研究者が参入しやすくなり、コストを削減し、スケールアップ生産の課題を克服する方法を見つけることができるようになるという利点があります。
＜関連情報＞
- https://now.tufts.edu/2023/05/11/another-step-away-farm-meat-grown-immortal-stem-cells
- https://pubs.acs.org/doi/10.1021/acssynbio.3c00216
培養食肉用の不死化ウシ肉幹細胞 Immortalized Bovine Satellite Cells for Cultured Meat Applications
Andrew J. Stout, Miles J. Arnett, Kristin Chai, Tina Guo, Lishu Liao, Addison B. Mirliani, Miriam L. Rittenberg, Michelle Shub, Eugene C. White, John S. K. Yuen Jr., Xiaoli Zhang, and David L. Kaplan
ACS Synthetic Biology Published:May 5, 2023
DOI:https://doi.org/10.1021/acssynbio.3c00216
Abstract
For cultured meat to succeed at scale, muscle cells from food-relevant species must be expanded in vitro in a rapid and reliable manner to produce millions of metric tons of biomass annually. Toward this goal, genetically immortalized cells offer substantial benefits over primary cells, including rapid growth, escape from cellular senescence, and consistent starting cell populations for production. Here, we develop genetically immortalized bovine satellite cells (iBSCs) via constitutive expression of bovine Telomerase reverse transcriptase (TERT) and Cyclin-dependent kinase 4 (CDK4). These cells achieve over 120 doublings at the time of publication and maintain their capacity for myogenic differentiation. They therefore offer a valuable tool to the field, enabling further research and development to advance cultured meat.
