マイクロ流路を流れる柔らかい粒子の集まり方を解明~スーパーコンピュータ「富岳」が解き明かす,細胞選別の新原理~

2025-09-22 大阪大学

大阪大学を中心とする研究チームは、マイクロ流路内での柔らかい粒子の集束パターンが、その変形性によって劇的に変化することを解明しました。硬い粒子は流路壁近くに集まるのに対し、柔らかいヒドロゲル粒子は断面中心や対角線上に集まることを実験で確認。スーパーコンピュータ「富岳」を用いた大規模シミュレーションと新理論モデルにより、レイノルズ数とキャピラリー数を指標とした相図を構築し、相転移的に集束位置が変化する条件を明らかにしました。本成果はJournal of Fluid Mechanicsに掲載され、細胞の変形性を利用した新しいマイクロ流体デバイス開発や、がんの早期診断につながる高効率な細胞選別技術への応用が期待されます。

マイクロ流路を流れる柔らかい粒子の集まり方を解明~スーパーコンピュータ「富岳」が解き明かす,細胞選別の新原理~

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正方形流路内を懸濁するハイドロゲル粒子の慣性移動に関する実験的・数値的研究 Experimental and numerical study on the inertial migration of hydrogel particles suspended in square channel flows

Yuma Hirohata,Kazusa Sai,Yuki Tange,Tomohiro Nishiyama,Haruka Minato,Daisuke Suzuki,Tomoaki Itano,Kazuyasu Sugiyama and Masako Sugihara-Seki
Journal of Fluid Mechanics  Published:18 September 2025
DOI:https://doi.org/10.1017/jfm.2025.10574

Abstract

The inertial migration of hydrogel particles suspended in a Newtonian fluid flowing through a square channel is studied both experimentally and numerically. Experimental results demonstrate significant differences in the focusing positions of the deformable and rigid particles, highlighting the role of particle deformability in inertial migration. At low Reynolds numbers (Re), hydrogel particles migrate towards the centre of the channel cross-section, whereas the rigid spheres exhibit negligible lateral motion. At finite Re, they focus at four points along the diagonals in the downstream cross-section, in contrast to the rigid particles which focus near the centre of the channel face at similar Re. Numerical simulations using viscous hyperelastic particles as a model for hydrogel particles reproduced the experimental results for the particle distribution with an appropriate Young’s modulus of the hyperelastic particles. Further numerical simulations over a broader range of Re and the capillary number (Ca) reveal various focusing patterns of the particles in the channel cross-section. The phase transitions between them are discussed in terms of the inertial lift and the lift due to particle deformation, which would act in the direction towards lower shear. The stability of the channel centre is analysed using an asymptotic expansion approach to the migration force at low Re and Ca. The theoretical analysis predicts the critical condition for the transition, which is consistent with the direct numerical simulation. These experimental, numerical and theoretical results contribute to a deeper understanding of inertial migration of deformable particles.

1700応用理学一般
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