2025-11-21 パシフィック・ノースウェスト国立研究所（PNNL）
By coordinating with zinc, specially designed peptoids help convert bicarbonate into carbonate and reorganize water layers on calcite surfaces.(Image by Nathan Johnson | Pacific Northwest National Laboratory)
＜関連情報＞
- https://www.pnnl.gov/publications/enzyme-mimic-peptoids-accelerate-calcite-growth-kinetics
- https://advanced.onlinelibrary.wiley.com/doi/10.1002/adfm.202522918
ヒスチジン含有ペプトイドによる方解石成長の速度論的促進の役割 Role of Histidine-Containing Peptoids in Accelerating the Kinetics of Calcite Growth
Mingyi Zhang, Ying Chen, Chenyang Shi, Progyateg Chakma, James J. De Yoreo, Chun-Long Chen
Advanced Functional Materials Published: 10 November 2025
DOI:https://doi.org/10.1002/adfm.202522918
Abstract
Carbonate mineralization, the conversion of CO2 into stable, thermodynamically favorable carbonate minerals, offers a promising strategy for permanent and environmentally friendly carbon storage, with minimal risk of long-term leakage and minimal monitoring requirements. Drawing inspiration from carbonic anhydrase (CA), a family of zinc-containing metalloenzymes that catalyze the hydration of CO2 to bicarbonate and promote carbonate precipitation, a class of histidine-containing peptoids was designed that is capable of coordinating with Zn2+ ions to act as CA mimetics for accelerating calcite step growth. In situ atomic force microscopy (AFM) measurements reveal that these peptoids significantly enhance step advancement, with a more pronounced effect observed when combined with Zn2+ ions and under higher calcium-to-carbonate activity ratios, indicating that peptoids facilitate the incorporation of CO32− ions at step edges. Solution NMR and 3D atomic force microscopy (3D AFM) analyses show that the coordination of peptoids with Zn2+ promotes both the deprotonation of HCO3− to CO32− and restructures the interfacial hydration layers of calcite, collectively lowering the activation barrier for step growth. These findings establish a design framework for sequence-defined polymers to regulate carbonate mineralization, offering promising applications in CO2 capture and long-term storage.
