2025-09-15 パシフィック・ノースウェスト国立研究所 (PNNL)
Designed peptoid assemblies exhibited catalytic activity toward hydrating CO2 to bicarbonate and accelerate the conversion of bicarbonate to carbonate. (Image by Nathan Johnson | Pacific Northwest National Laboratory)
＜関連情報＞
- https://www.pnnl.gov/publications/crystalline-peptoid-nanomaterials-promoting-carbon-dioxide-dissolution-and
- https://www.nature.com/articles/s41467-025-62366-w
炭酸脱水酵素模倣体としてのペプトイド結晶性ナノ材料の組み立て：CO2の水和促進と隔離への応用 Assembled peptoid crystalline nanomaterials as carbonic anhydrase mimics for promoted hydration and sequestration of CO2
Progyateg Chakma,Ying Chen,Bradley S. Harris,Yasmene W. Elhady,Renyu Zheng,Mark E. Bowden,Vaithiyalingam Shutthanandan,Alexander B. Bard,Thi Kim Hoang Trinh,Xueyun Zheng,Christopher J. Mundy,Marcel D. Baer & Chun-Long Chen
Nature Communications Published:09 August 2025
DOI:https://doi.org/10.1038/s41467-025-62366-w
Abstract
Carbonic anhydrase (CA) mimics have received significant attention due to their promising applications in the enhanced hydration and sequestration of CO2. Herein, we report the assembly of sequence-defined peptoids into crystalline nanomaterials with controlled microenvironment of active sites as CA mimics for promoted hydration and sequestration of CO2. By incorporating specific ligands into self-assembling peptoids and coordinating these ligands with metal cations, we synthesize a variety of crystalline nanosheets and nanotubes as efficient CA mimics comparable to natural bovine CA. Molecular dynamics simulations reveal the critical roles of peptoid-Zn2+ binding energy and the active site local microenvironment on the catalytic performance of these CA mimics. CO2 precipitation results show that these CA mimics promote the hydration and sequestration of CO2 while retaining high thermal and chemical stabilities. This study offers essential guidance for the future design of high-performance CA-mimics suitable for applications in CO2 capture and sequestration.
