2025-03-05 カリフォルニア大学バークレー校 (UCB)
＜関連情報＞
- https://newscenter.lbl.gov/2025/03/05/for-better-quantum-sensing-go-with-the-flow/
- https://www.science.org/doi/10.1126/sciadv.adp4033
流れる単分散微小液滴における高精度化学量子センシング(High-precision chemical quantum sensing in flowing monodisperse microdroplets)
Adrisha Sarkar, Zachary R. Jones, Madhur Parashar, Emanuel Druga, […], and Ashok Ajoy
Science Advances Published:11 Dec 2024
DOI:https://doi.org/10.1126/sciadv.adp4033
Abstract
A method is presented for high-precision chemical detection that integrates quantum sensing with droplet microfluidics. Using nanodiamonds (ND) with fluorescent nitrogen-vacancy (NV) centers as quantum sensors, rapidly flowing microdroplets containing analyte molecules are analyzed. A noise-suppressed mode of optically detected magnetic resonance is enabled by pairing controllable flow with microwave control of NV electronic spins, to detect analyte-induced signals of a few hundredths of a percent of the ND fluorescence. Using this method, paramagnetic ions in droplets are detected with low limit-of-detection using small analyte volumes, with exceptional measurement stability over >103 s. In addition, these droplets are used as microconfinement chambers by co-encapsulating ND quantum sensors with various analytes such as single cells, suggesting wide-ranging applications including single-cell metabolomics and real-time intracellular measurements from bioreactors. Important advances are enabled by this work, including portable chemical testing devices, amplification-free chemical assays, and chemical imaging tools for probing reactions within microenvironments.
