2025-11-17 中国科学院（CAS）
Figure 1. (a) Principle of ES-AuAgNPs synthetization. (b) TEM images of ES-AuAgNPs fabricated with various HAuCl4 concentrations. (c) SEM image of the optimized ES-AuAgNPs, along with EDS mapping and electric field simulation. (Image by Prof. CHEN Lingxin’s team)
＜関連情報＞
- https://english.cas.cn/newsroom/research_news/chem/202511/t20251117_1115891.shtml
- https://advanced.onlinelibrary.wiley.com/doi/10.1002/advs.202516240
ビブリオ菌のスクリーニング、検証、除去のための多機能エッジサテライトAuAgナノ粒子ベースの統合プラットフォーム Multifunctional Edged-Satellite AuAg Nanoparticles-Based Integration Platform for Screening, Validation, and Elimination of Vibrio Bacteria
Yixuan Wu, Jiadong Chen, Liyan Bi, Zhiyang Zhang, Xiaoyan Wang, Longwen Fu, Qian Yang, Jaebum Choo, Lingxin Chen
Advanced Science Published: 05 November 2025
DOI:https://doi.org/10.1002/advs.202516240
Abstract
Multifunctional materials converge various physical and chemical properties, while often being hampered by complicated synthesis procedures and inconsistent performance. A straightforward strategy is presented for synthesizing robust multifunctional plasmonic nanoparticles (NPs), AuAgNPs with edged satellites (ES-AuAgNPs). The ES-AuAgNPs possess various characteristics of i) alloyed Ag/Au with a 7:3 ratio, ii) numerous satellited NPs with narrow nanogaps on face-to-face edges, and iii) a well-accessible surface deposited with antimicrobial components. These properties endow ES-AuAgNPs with improved peroxidase (POD)-like catalytic, surface-enhanced Raman scattering (SERS), and antibacterial activities. By utilizing the triple-performance of ES-AuAgNPs and a modified specific aptamer probe, a portable, modular, and centimeter-sized platform is designed for simultaneously screening, validating, and eliminating pandemic marine Vibrio bacteria: parahaemolyticus, vulnificus, and alginolyticus. Wherein, POD-like catalytic-based colorimetric capacity can rapidly screen the presence of these bacteria through visible color change, and SERS-based detection validates bacterial identity with multiplexing capability. Meanwhile, the inherent antibacterial properties of ES-AuAgNPs ensure the effective elimination of detected bacteria. Remarkable performance is achieved in rapid screening (2 min), sensitive validation (limit of detection, ≈50 CFU per mL), and efficient antimicrobility (45 min, 100%). The ES-AuAgNPs constructed platform is believed to improve aquaculture management by seamlessly analyzing and eliminating bacteria.
