2024-04-04 マサチューセッツ工科大学(MIT)
＜関連情報＞
- https://news.mit.edu/2024/researchers-3d-print-key-components-affordable-mass-spectrometer-0404
- https://pubs.acs.org/doi/10.1021/jasms.3c00409
高性能、低コスト、積層造形による質量分析用エレクトロスプレーイオン源 High-Performance, Low-Cost, Additively Manufactured Electrospray Ion Sources for Mass Spectrometry
Alex Kachkine and Luis Fernando Velásquez-García
Journal of the American Association for Mass Spectrometry Published:March 22, 2024
DOI:https://doi.org/10.1021/jasms.3c00409
Abstract
We report novel 3D-printed electrospray sources for mass spectrometry (MS) that produce twice the signal strength of their mainstream counterparts. Leveraging 3D printing to fabricate in bulk nano- and microscale-featured electrospray emitters, this work shows a path for scalable integration in clinically relevant diagnostics. This solution improves the device performance by simultaneously tuning the surface hydrophilicity, solvent evaporation, and geometry. The emitters are made of stainless-steel (SS) 316L via binder jetting and coated in a conformal, hydrothermally grown zinc oxide nanowire (ZnONW) forest. The printed emitters are designed as surface mount devices that can be directly soldered to printed circuit boards with built-in digital microfluidics as part of an automated device assembly. The electrospray sources use a novel extractor electrode design that enables operation at ∼24% larger bias voltages compared with conventional MS cylindrical inlets. The 3D-printed electrospray emitters were characterized against their state-of-the-art counterparts (coated blades and paper spray). MS data from the 3D-printed electrospray emitters show detection of therapeutically relevant targets at 1 μg/ml concentrations with a variety of solvents; for nicardipine, such emitters attain 116% higher signal-to-noise ratios and far greater stability than their counterparts.
